MADRID: Scot Andy Murray stormed to the third round as good fortune ran out for Italian lucky loser Simone Bolelli 6-0, 2-1 retired.
The Italian, who earned a place in the draw when Marat Safin withdrew with injury, threw in the towel after 47 minutes after treatment on an upper arm and shoulder.
Murray next faces Croatian Marin Cilic, who put out 13th-seeded Spaniard Fernando Verdasco 6-2, 6-3.
Cilic, 20 and Murray, a year older, have never played on the ATP Tour though they met in Davis Cup two years ago and as juniors in Paris, standing 1-1.
American James Blake maintained his dismal, winless record in Madrid with the frustrated 11th seed crashing out to on-form Frenchman Gilles Simon 3-6, 6-1, 6-4.
Simon, winner of two titles since July, pounced on 46 unforced errors to hand Blake his fifth loss in the Spanish capital and put the American in grave danger of dropping in the race for the season-ending Masters Cup in Shanghai.
The 16th-ranked Simon is riding a wave of form after winning Indianapolis and Bucharest in recent months.
Blake's potential for a spot in China is endangered if Swiss Stan Wawrinka can do well this week while standing tenth in the points race one spot behind the fading Blake.
In first-round matches, Germany's Philip Kohlschreiber stopped Spanish hero Carlos Moya 6-2, 6-2 while Marcel Granollers of Spain beat Frenchman Paul-Henri Mathieu 6-4, 6-4.
Weekend Vienna finalist Gael Monfils continued his indoor success as he beat Italian wild card Fabio Fognini 6-2, 6-4. Stockholm semi-finalist Jarkko Nieminen reversed a run of three losses against Mikhail Youzhny, ousting the Russian 7-5, 3-6, 6-2.
The 2005 semi-finalist Robby Ginepri of the US beat Frenchman Michael Llodra 6-4, 6-4, with Swede Robin Soderling adding another French loss with his defeat of Florent Serra 6-3, 6-4.