Goals from Andres Iniesta, Cesc Fabregas, and a brace from Lionel Messi on Sunday saw the Catalans ease past Levante 4-0. Victory moved Vilanova's side well clear of bitter rivals Real, but the club remain just three points ahead of second-placed Atletico Madrid following 13 rounds.
"La Liga is not over," Vilanova said on the club's website.
"We still have 75 points left to play for and Atletico Madrid are only three points behind us. We have a long way to go!".
He added: "They [Atletico] are very solid and strong this year, and they ended last season on form."
Barca could actually extend their lead once again next weekend when Atletico face Real at the Bernabeu.
Not that Vilanova was interested to know.
"Next weekend we have to beat Athletic Club Bilbao. We don't care about what happens between Real Madrid and Atletico Madrid. We can't do anything about that game," he said.
However, Vilanova did admit that he was proud of that 11 graduates from the club's famous La Masia academy played and beat Levante on Sunday.
"It's something that should make us happy, seven or eight of them are Catalan. We have to be proud," he said.
Atletico stretched their 100% record at the Vicente Calderon this season to 10 games with a comprehensive 4-0 victory over nine-man Sevilla at the weekend.